Iosif Gershteyn

The key pathogenetic mechanisms of COVID-19 involve tissue damage, inflammation, and thrombosis. Based on pathogenetic mechanisms of this disease, our initial literature search, prior to the first wave of COVID-19, identified well-known, inexpensive, and widely available medications (indomethacin, famotidine and azithromycin), which could target multiple components of pathophysiologic process triggered by SARS-CoV-2. We describe three adult patients managed via telemedicine, discuss details of treatment, including medication dosages, and propose ambulatory implementation of this approach for preventing progression of the disease to a stage requiring hospitalization. We discuss some key goals related to prompt delivery of treatment to adult patients facilitated by telemedicine, aimed at reducing risks of spread of infection, and accelerating treatment initiation.

One of the most troubling developments of 2021 has been the number of fertile-aged women who have been led to believe that vaccines against SARS-CoV-2 (COVID-19) could cause infertility via cross-reactivity of immune response (specifically cross-reactivity of developed antibodies to Syncytin-1). The evidence does not support this claim.

In order to more effectively combat the coronavirus pandemic, the authors propose a system for daily analysis of residential wastewater at points of discharge from buildings. Results of testing should be used for the implementation of local quarantines as well as informed administration of tests for individuals.